New Antiproliferative Dibenzo-α-Pyrone From Whole Plants of Centella asiatica

A new compound, 1,3,7,9-tetrahydroxy-6 H-dibenzo[ b, d]pyran-6-one (1), together with 6 known compounds (2-7), was isolated from the extract of whole plants Centella asiatica. The chemical structure elucidated on basis spectroscopic and mass spectrometric analyses. All isolates were evaluated for their cytotoxicities against 4 human cancer cell lines (MCF-7, HepG2, Hela, A549). Among them, compound 1 found to exhibit significant cytotoxicity MCF-7 HepG2 cells half-maximal inhibitory concentration values 4.1 7.2 µM, respectively.